Table 3 Proffered diagnoses and immunohistochemical profile of 14 cases of myopericytoma or myofibroma.
Case | Diagnosis | Proffered diagnoses | Antigen | ||||||
---|---|---|---|---|---|---|---|---|---|
SMA | Desmin | S100 | HMB45 | Vimentin | CD34 | CK | |||
1 | MPC | Proliferating dermal tumour, probably malignant | 3+ | Negative | Negative | Negative | – | – | – |
2 | MPC | Infantile haemangiopericytoma | 3+ | – | – | Negative | – | – | – |
3 | MPC | Liposarcoma, monophasic synovial sarcoma, angiomatoid MFH | – | – | – | – | – | – | – |
4 | MPC | MPC | Positive | Patchy | Negative | – | – | – | Negative |
5 | MPC | Angioleiomyoma | + | – | Negative | – | – | – | – |
6 | MPC | MPC | Positive | Weak | Negative | Negative | – | – | – |
7 | MPC | Glomus tumour | Positive | Patchy | – | – | – | Negative | – |
8 | MF | ? Haemangioma | 1+ | Negative | – | – | – | Negative | – |
9 | MF | Solid angioleiomyoma | 3+ | Negative | 1+ (nuclei) | – | – | – | – |
10 | MF | Leiomyoma, fibroma, perineurioma | 3+ | Negative | Negative | – | – | – | – |
11 | MF | ?Leiomyosarcoma, angiomatoid MFH | Moderate | Occ cell | Negative | Negative | – | Negative | Negative |
12 | MF | MF | 3+ | Negative | Negative | Negative | Positive | – | Negative |
13 | MF | Giant cell tumour of tendon sheath, reparative giant cell granuloma | Positive | Neg | Negative | Negative | – | – | Negative |
14 | MF | ?AV malformation | Positive | Patchy | Negative | – | – | Negative | – |
Positive immunohistochemical staining was graded from weakly positive (1+) to strongly positive (3+).
AV, arteriovenous; CK, cytokeratin; MF, myofibroma; MFH, malignant fibrous histiocytoma; MPC, myopericytoma; SMA, smooth muscle actin; Occ, occasional; –, unknown.