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. 2006 May;59(5):454–459. doi: 10.1136/jcp.2005.025866

Table 1 Medline listed peer reviewed reports since 1995 examining the role of fine needle aspiration cytology in diagnosis of phyllodes tumour.

Authors Year Focus of study n (PT) Controls Blinding % PT with definite diagnosis on FNAC Comments
Shabalova et al60 1997 Diagnose benign and borderline PT 19 Yes (FA, fibrocystic disease, and carcinoma) No 32% Atypical changes in large proportion. Advise care in cytopathological diagnosis if myxoid stromal component
Shabb et al61 1997 Elucidate features of PT 8 No No N/A Discussion relates to distinguishing PT from FA. Advise multiple aspirates and thin smears
Deen et al62 1999 Distinguish FA and PT 19 Yes (FA) No N/A Overlapping spectrum. Suggest intermediate group of uncertain malignant potential
Bhattarai et al63 2000 Determine PT subtypes 80 No Yes 71.3% Good cytohistological correlation in 81%. Advise multiple site aspiration
Krishnamurthy et al64 2000 Distinguish FA and PT 12 Yes (FA) No 33.3% Long spindle nuclei comprising ⩾30% of dispersed stromal cells diagnostic of phyllodes tumour (10–30% = indeterminate)
Scolyer et al65 2001 Distinguish FA and PT 8 Yes (FA) Yes 62.5% Hypercellular stromal fragments most useful feature – presence should raise possibility of PT
Badhe et al66 2002 Distinguish FA and PT and determine subtypes 9 Yes (FA) Yes 77% Semiquantitative team approach improved diagnosis of FA
Jayaram et al67 2002 Diagnose PT and determine subtypes 28 No No 71.4% Criteria for diagnosis of benign PT = at least two of large stromal fragments, hypercellular stromal fragments, and moderate to large numbers of dissociated stromal cells
Shimizu et al68 2002 Distinguish FA and benign PT 18 Yes (FA) No N/A Size and shape of epithelial clusters provide additional clues (longer than 1 mm, wavy or folded in phyllodes tumour)
Totals 201 99/156 = 63% Indeterminate results excluded

FA, fibroadenoma; FNAC, fine needle aspiration cytology; PT, phylloides tumour.