Table 2 Lymphangiogenesis parameters related to conventional clinicopathological variables in 45 cutaneous melanomas.
| Variable | N | Mean (SD) intratumorous LVD | p Value | Mean (SD) intratumorous LVA (μm2) | p Value | Mean (SD) peritumorous LVD | p Value | Mean (SD) peritumorous LVA (μm2) | p Value |
|---|---|---|---|---|---|---|---|---|---|
| Age | 0.006 | 0.02 | 0.11 | 0.18 | |||||
| ⩽58 | 21 | 17.27 (11.04) | 588.73 (649.48) | 27.59 (14.07) | 2442.80 (2206.05) | ||||
| >58 | 24 | 29.27 (15.53) | 1320.81 (1472.52) | 33.72 (14.14) | 2770.22 (1616.62) | ||||
| Sex | 0.32 | 0.18 | 0.44 | 0.92 | |||||
| Male | 27 | 25.27 (15.38) | 1105.51 (1307.89) | 29.35 (12.73) | 2514.19 (1580.06) | ||||
| Female | 18 | 21.27 (13.87) | 789.66 (1050.43) | 33.11 (16.47) | 2772.27 (2339.09) | ||||
| Site | 0.15 | 0.56 | 0.84 | 0.80 | |||||
| Upper extremity | 9 | 21.08 (13.66) | 631.48 (463.89) | 28.50 (15.09) | 2114.46 (1373.86) | ||||
| Lower extremity | 11 | 21.65 (14.38) | 726.06 (600.08) | 28.78 (14.77) | 2194.92 (1269.03) | ||||
| Trunk | 19 | 22.07 (15.16) | 917.26 (1065.21) | 31.53 (13.98) | 3085.74 (2433.10) | ||||
| Head and neck | 3 | 34.40 (8.40) | 2775.79 (3056.31) | 35.53 (6.92) | 2289.12 (1540.16) | ||||
| Acral regions | 3 | 38.17 (17.70) | 1545.78 (1919.60) | 36.63 (23.35) | 3037.79 (1854.07) | ||||
| Thickness (mm) | 0.65 | 0.25 | 0.88 | 0.16 | |||||
| ⩽1.0 | 6 | 21.08 (16.95) | 655.12 (617.05) | 34.41 (19.28) | 2209.67 (1155.04) | ||||
| 1.01–2.0 | 12 | 19.68 (9.37) | 568.96 (601.02) | 29.68 (13.88) | 3111.75 (2541.82) | ||||
| 2.01‐4.0 | 19 | 27.15 (15.59) | 1137.77 (1517.26) | 30.15 (14.80) | 1967.76 (1278.24) | ||||
| >4.0 | 8 | 23.31 (18.36) | 1460.86 (1309.97) | 31.63 (11.66) | 3724.71 (2061.08) | ||||
| Level | 0.53 | 0.57 | 0.58 | 0.82 | |||||
| III | 31 | 23.84 (14.73) | 1052.39 (1398.92) | 30.18 (13.57) | 2711.43 (2007.76) | ||||
| IV | 10 | 26.82 (15.86) | 935.76 (663.60) | 35.00 (16.12) | 2381.03 (1234.00) | ||||
| V | 4 | 14.45 (11.26) | 520.24 (450.96) | 25.80 (16.62) | 2479.90 (2774.74) | ||||
| Ulceration | 0.15 | 0.0001 | 0.25 | 0.008 | |||||
| Absent | 33 | 21.48 (13.78) | 636.47 (738.69) | 29.57 (15.02) | 2409.99 (1983.74) | ||||
| Present | 12 | 29.69 (16.30) | 1921.60 (1713.72) | 34.40 (11.91) | 3187.86 (1578.02) | ||||
| Histotype | 0.25 | 0.73 | 0.79 | 0.43 | |||||
| SSM | 26 | 20.42 (12.73) | 850.57 (967.93) | 30.61 (13.89) | 2700.39 (2188.45) | ||||
| NM | 15 | 26.86 (16.50) | 1112.61 (1505.47) | 29.98 (14.52) | 2328.31 (1444.93) | ||||
| ALM | 4 | 32.78 (18.03) | 1314.65 (1364.09) | 35.80 (19.13) | 3162.30 (1534.18) | ||||
| Regression | 0.82 | 0.30 | 0.49 | 1.0 | |||||
| Absent | 34 | 23.20 (14.45) | 927.65 (1259.40) | 29.97 (14.40) | 2393.58 (1214.22) | ||||
| Present | 11 | 25.11 (16.35) | 1138.43 (1077.02) | 33.60 (14.25) | 3309.30 (3209.70) | ||||
| Tumour growth phase | 0.44 | 0.003 | 0.38 | 0.006 | |||||
| Radial | 6 | 17.73 (13.09) | 331.32 (403.12) | 25.51 (11.28) | 1447.87 (1130.39) | ||||
| Vertical | 39 | 24.58 (14.95) | 1078.84 (1262.75) | 31.68 (14.64) | 2797.36 (1938.43) | ||||
| Inflammatory infiltrate | 0.04 | 0.96 | 0.05 | 0.82 | |||||
| Absent/sparse | 22 | 18.99 (12.62) | 995.73 (1336.99) | 26.64 (12.80) | 2544.79 (1446.31) | ||||
| Moderate/pronounced | 23 | 28.14 (15.53) | 963.33 (1102.90) | 34.89 (14.73) | 2686.90 (2281.23) | ||||
| SLN | 0.04 | 0.001 | 0.003 | 0.007 | |||||
| Negative | 30 | 19.01 (10.30) | 717.97 (1182.75) | 26.86 (13.50) | 2075.86 (1450.36) | ||||
| Positive | 15 | 32.98 (18.07) | 1501.56 (1121.29) | 38.86 (12.69) | 3700.55 (2255.86) | ||||
| Status | 0.30 | 0.06 | 0.07 | 0.13 | |||||
| Alive | 31 | 21.90 (13.33) | 900.62 (1327.46) | 28.24 (13.07) | 2282.78 (1497.54) | ||||
| Dead | 14 | 27.57 (17.45) | 1153 (912.77) | 36.65 (15.6) | 3358.43 (2483.89) |
ALM, acral lentiginous melanoma; LVA, lymphatic vessel area; LVD, lymphatic vessel density; NM, nodular melanoma; SLN, sentinel lymph node; SSM, superficial spreading melanoma.