Table 2 Median values (n, %) of different discrete clinicopathological features for sporadic breast cancers, cancers in patients with BRCA1 or BRCA2 mutations and in patients with breast cancer who are at different risks of hereditary disease on the basis of family history.
| Type | Sporadic (n, %) | Intermediate risk of hereditary disease (n, %) | High risk of hereditary disease (n, %) | Mutations in BRCA1 (n, %) | Mutations in BRCA2 (n, %) | |
|---|---|---|---|---|---|---|
| Grade | 1 | 119 (22) | 9 (16) | 0 (0) | 0 (0) | 0 (0) |
| 2 | 181 (34) | 25 (46) | 5 (26) | 4 (18) | 1 (20) | |
| 3 | 232 (44) | 21 (38) | 14 (74) | 18 (82) | 4 (80) | |
| Histological type | Ductal | 474 (79) | 55 (84) | 14 (74) | 18 (82) | 5 (100) |
| Lobular | 56 (9) | 8 (12) | 1 (5) | 0 (0) | 0 (0) | |
| Medullary | 10 (2) | 0 (0) | 1 (5) | 4 (18) | 0 (0) | |
| Tubular | 22 (4) | 1 (2) | 0 (0) | 0 (0) | 0 (0) | |
| Other | 42 (7) | 1 (2) | 3 (16) | 0 (0) | 0 (0) | |
| EGFR | Neg | 360 (84) | 24 (77) | 3 (20) | 7 (33) | 0 (0) |
| Pos | 70 (16) | 7 (23) | 12 (80) | 14 (67) | 5 (100) | |
| HER‐2/neu | Neg | 374 (87) | 52 (88) | 15 (83) | 17 (81) | 3 (75) |
| Pos | 55 (13) | 7 (12) | 3 (17) | 4 (19) | 1 (25) |
EGFR, epidermal growh factor receptor; Neg, negative; Pos, positive.