Table 2 Univariate analysis (Kaplan–Meier, log‐rank test) for prognostic significance of cyclo‐oxygenase‐2, histological grading, phospho‐Akt (serine 473 and threonine 308), receptor status, HER‐2/neu, mitotic count, tumour size and phospho‐p38.

Parameter	p
COX‐2 (negative/positive)	0.0191
Histological grade	0.0010
pAkt (473) (negative/positive)	0.0190
pAkt (308) (negative/positive)	NS
ER status	NS
HER‐2 status	NS
MC (0–8, 9–16, >16)	0.0393*
Tumour size	NS
pp38 (negative/intermediate/positive)	NS

COX, cyclo‐oxygenase; ER, oestrogen receptor; MC, mitotic count; NS, not significant; pAkt, phospho‐Akt; pp38, phospho‐p38.