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. 2006 Feb 7;59(8):827–830. doi: 10.1136/jcp.2005.030726

Table 4 Analysis of concordance between three observers in the study and control groups.

Diagnosis Modified counterstain Conventional counterstain Conventional counterstain and smear test
κ* 95% CI p Value† κ* 95% CI p Value† κ* 95% CI p Value†
WNL 0.842 0.616 to 1.069 <0.001 0.435 0.225 to 0.645 <0.001 0.284 0.127 to 0.440 0.004
ASC‐US 0.306 0.079 to 0.532 0.004 0.174 −0.036 to 0.384 0.052 0.380 0.224 to 0.537 <0.001
ASC‐H −0.042 −0.268 to 0.185 0.641 −0.088 −0.298 to 0.123 0.793 −0.061 −0.218 to 0.096 0.715
LSIL 0.781 0.554 to 1.007 <0.001 0.731 0.521 to 0.942 <0.001 0.839 0.682 to 0.995 <0.001
HSIL 0.945 0.719 to 1.171 <0.001 0.761 0.551 to 0.971 <0.001 0.815 0.658 to 0.971 <0.001
Combined‡ 0.773 0.622 to 0.923 <0.001 0.549 0.427 to 0.671 <0.001 0.642 0.544 to 0.739 <0.001

ASC‐H, abnormal squamous cells, high‐grade lesion cannot be excluded; ASC‐US, abnormal squamous cells of undetermined significance; HSIL, high‐grade squamous intraepithelial lesion; LSIL, low‐grade squamous intraepithelial lesion; WNL, within normal limits.

*Landis–Koch extension.

†p Value for the test z (for κ = 0).

‡Combined κ (Fleiss–Nee–Landis test).