Table 4 Analysis of concordance between three observers in the study and control groups.
Diagnosis | Modified counterstain | Conventional counterstain | Conventional counterstain and smear test | ||||||
---|---|---|---|---|---|---|---|---|---|
κ* | 95% CI | p Value† | κ* | 95% CI | p Value† | κ* | 95% CI | p Value† | |
WNL | 0.842 | 0.616 to 1.069 | <0.001 | 0.435 | 0.225 to 0.645 | <0.001 | 0.284 | 0.127 to 0.440 | 0.004 |
ASC‐US | 0.306 | 0.079 to 0.532 | 0.004 | 0.174 | −0.036 to 0.384 | 0.052 | 0.380 | 0.224 to 0.537 | <0.001 |
ASC‐H | −0.042 | −0.268 to 0.185 | 0.641 | −0.088 | −0.298 to 0.123 | 0.793 | −0.061 | −0.218 to 0.096 | 0.715 |
LSIL | 0.781 | 0.554 to 1.007 | <0.001 | 0.731 | 0.521 to 0.942 | <0.001 | 0.839 | 0.682 to 0.995 | <0.001 |
HSIL | 0.945 | 0.719 to 1.171 | <0.001 | 0.761 | 0.551 to 0.971 | <0.001 | 0.815 | 0.658 to 0.971 | <0.001 |
Combined‡ | 0.773 | 0.622 to 0.923 | <0.001 | 0.549 | 0.427 to 0.671 | <0.001 | 0.642 | 0.544 to 0.739 | <0.001 |
ASC‐H, abnormal squamous cells, high‐grade lesion cannot be excluded; ASC‐US, abnormal squamous cells of undetermined significance; HSIL, high‐grade squamous intraepithelial lesion; LSIL, low‐grade squamous intraepithelial lesion; WNL, within normal limits.
*Landis–Koch extension.
†p Value for the test z (for κ = 0).
‡Combined κ (Fleiss–Nee–Landis test).