Table 6 Histological evaluation of the inflammatory cells in bullous skin lesions with subepidermal bullae.
| DH n = 7 | BP n = 5 | BDE n = 1 | CCD n = 1 | EB n = 2 | CBDC n = 2 | LPA n = 1 | ||
|---|---|---|---|---|---|---|---|---|
| Histiocytes | Total | 36.0 (5.2) | 12.0 (2.00) | 60 | 9.0 | 30.0 (6.00) | 22.0 (9.0) | 3.0 |
| Epidermis | 0.20 (0.2) | 0 (0) | 0 | 0 | 0.50 (0.50) | 0 (0) | 0 | |
| Bullae (inside) | 16.4 (2.9) | 3.00 (1.60) | 51 | 0 | 2.50 (0.50) | 3.50 (0.5) | 0 | |
| Bullae (around) | 0 (0) | 1.00 (0.60) | 0 | 0 | 0 | 3.00 | 0 | |
| DEJ | 3.20 (1) | 3.40 (0.40) | 0 | 5.0 | 6.00 (1.00) | 7.00 (4.0) | 0 | |
| Perivascular | 20.2 (2.7) | 5.40 (1.30) | 9.0 | 4.0 | 20.5 (4.50) | 10.0 (6.0) | 3.0 | |
| Lymphocytes | Total | 28.0 (8) | 19.0 (5.40) | 35 | 39 | 24.0 (19.0) | 36.0 (6.0) | 50 |
| Epidermis | 0 (0) | 0 (0) | 0 | 0 | 0 (0) | 0 (0) | 0 | |
| Bullae (inside) | 4.90 (2.7) | 4.80 (2.80) | 19 | 7.0 | 11.5 (10.5) | 3.50 (3.5) | 0 | |
| Bullae (around) | 0 (0) | 1.80 (1.10) | 0 | 1.0 | 0 | 0 | 0 | |
| DEJ | 1.40 (1.00) | 2.00 (1.00) | 0 | 1.0 | 1.50 (1.50) | 3.50 (1.5) | 0 | |
| Perivascular | 26.3 (9.30) | 10.6 (2.90) | 16 | 30 | 11.0 (7.00) | 29.0 (1.0) | 50 | |
| Neutrophils | Total | 98.0 (51.0) | 18.0 (12.0) | 3.0 | 1.0 | 59.0 (59.0) | 18.0 (18.0) | 0 |
| Epidermis | 0 (0) | 0 (0) | 0 | 0 | 0 (0) | 0 (0) | 0 | |
| Bullae (inside) | 62.6 (25.7) | 3.00 (3.00) | 3.0 | 1.0 | 34.0 (34.0) | 15.0 (15.0) | 0 | |
| Bullae (around) | 0 (0) | 0.40 (0.40) | 0 | 0 | 0 | 0 | 0 | |
| DEJ | 0.40 (0.40) | 0.80 (0.50) | 0 | 0 | 10.0 (10.0) | 1.00 (1.0) | 0 | |
| Perivascular | 41.2 (32.3 | 13.8 (12.6) | 0 | 0 | 30.0 | 1.50 (1.5) | 0 | |
| Eosinophils | Total | 7.30 (6.00) | 5.40 (3.00) | 1.0 | 0 | 0.50 (0.50) | 0 (0) | 0 |
| Epidermis | 0 (0) | 0 (0) | 0 | 0 | 0 (0) | 0 (0) | 0 | |
| Bullae (inside) | 4.40 (3.70) | 2.00 (2.00) | 1.0 | 0 | 0.50 (0.50) | 0 (0) | 0 | |
| Bullae (around) | 0 (0) | 0.40 (0.40) | 0 | 0 | 0 | 0 | 0 | |
| DEJ | 0 (0) | 0.40 (0.20) | 0 | 0 | 0 (0) | 0 (0) | 0 | |
| Perivascular | 3.30 (2.60) | 2.60 (1.30) | 0 | 0 | 0 | 0 (0) | 0 | |
| Plasma cells | Total | 0 (0) | 0 (0) | 0 | 0 | 0 (0) | 0 (0) | 0 |
| Epidermis | 0 (0) | 0 (0) | 0 | 0 | 0 (0) | 0 (0) | 0 | |
| Bullae (inside) | 0 (0) | 0 (0) | 0 | 0 | 0 | 0 (0) | 0 | |
| Bullae (around) | 0 (0) | 0 (0) | 0 | 0 | 0 | 0 | 0 | |
| DEJ | 0 (0) | 0 (0) | 0 | 0 | 0 (0) | 0 (0) | 0 | |
| Perivascular | 0 (0) | 0 (0) | 0 | 0 | 0 | 0 (0) | 0 | |
BDE, bullous drug eruption (with subepidermal bullae); BP, bullous pemphigoid; CBDC, chronic bullous disease of childhood; CCD, chronic contact dermatitis; DEJ, dermoepidermal junction; DH, dermatitis herpetiformis; EB, epidermolysis bullosa..
Inflammatory cells were counted in three different fields (sections stained with haematoxylin and eosin, 400×). Values are expressed as mean (SEM).