Table 1 Characteristics of siblings.

	Affected siblings n = 416	Unaffected siblings n = 490	p Value
Mean (SD) age when CAD diagnosed (years)	45.6 (6.2) (males)	N/A	N/A
	48.8 (6.6) (females)
Mean (SD) age at study entry (years)	51.0 (7.5) (males)	55.1 (8.8) (males)	<0.001
	52.4 (7.7) (females)	56.1 (7.7) (females)	<0.001
% Male	79.6	47.1	<0.001
% Non‐smokers	18.0	42.4	<0.001
% Hypertension	29.6	46.7	<0.001
% Diabetes mellitus	10.6	4.5	<0.001
% Hypercholesterolaemia	93.0	82.9	<0.001

Non‐smokers defined as lifelong non‐smokers; hypertension defined as personal history of hypertension or systolic blood pressure > 140 mm Hg or diastolic blood pressure > 95 mm Hg; hypercholesterolaemia defined as current treatment with a lipid lowering agent or total serum cholesterol > 5.0 mmol/l; diabetes mellitus defined as a personal history of diabetes or random blood glucose > 11.1 mmol/l.