Table 1 Determinants of diastolic function.
• Myocardial relaxation |
- load |
- inactivation (calcium homeostasis, myofilaments, energetics) |
- non‐uniformity |
• Passive properties of ventricular wall |
- myocardial stiffness (cytoskeleton, extracellular matrix) |
- wall thickness |
- chamber geometry |
• Other determinants |
- structures surrounding the ventricle (pericardium, lungs, remaining cardiac chambers) |
- left atrium, pulmonary veins and mitral valve |
- heart rate |