Table 2 Outcome of TPG before and after treatment with prostacyclin in five patients.
1 | 2 | 3 | 4 | 5 | Mean (SD) | p Value* | |
---|---|---|---|---|---|---|---|
Duration of treatment before repeat catheterisation (days) | 51 | 49 | 36 | 78 | 75 | 58 (18) | |
Before long term prostacyclin treatment | |||||||
At catheterisation baseline | |||||||
Mean PA pressure (mm Hg) | 61 | 66 | 36 | 41 | 50 | 51 (12.7) | |
Mean LA pressure (mm Hg) | 33 | 24 | 21 | 18 | 22 | 24 (5.7) | |
TPG (mm Hg) | 28 | 42 | 15 | 23 | 28 | 27 (9.8) | |
CI (l/min/m2) | 1.7 | 5.5 | 1.9 | 1.6 | |||
With acute vasodilator testing | |||||||
Mean PA pressure (mm Hg) | 43 | 58 | 31 | 34 | 42 | 42 (10.5) | |
Mean LA pressure (mm Hg) | 33 | 28 | 15 | 16 | 23 | 23 (7.7) | |
TPG (mm Hg) | 11 | 30 | 16 | 18 | 19 | 19 (6.8) | |
CI (l/min/m2) | 2.3 | 5.5† | 1.9 | 1.6 | |||
During long term prostacyclin treatment | |||||||
At catheterisation baseline | |||||||
Mean PA pressure (mm Hg) | 48 | 50 | 29 | 34 | 42 | 41 (9.0) | <0.01 |
Mean LA pressure (mm Hg) | 31 | 25 | 20 | 17 | 20 | 23 (5.5) | 0.14 |
TPG (mm Hg) | 17 | 25 | 9 | 17 | 22 | 17 (6.7) | 0.01 |
CI (l/min/m2) | 3.5 | 2.6 | 1.2 | 1.6 | |||
With acute vasodilator testing | |||||||
Mean PA pressure (mm Hg) | 44 | 38 | 26 | 33 | 38 | 35.8 (6.7) | 0.19 |
Mean LA pressure (mm Hg) | 43 | 22 | 19 | 20 | 17 | 24.2 (10.7) | 0.722 |
TPG (mm Hg) | 2 | 16 | 7 | 13 | 21 | 11 (7.5) | <0.05 |
CI (l/min/m2) | 4.7 | 2.8 | 1.2 | 1.5 |
Data are mean (SD).
*Before versus during treatment with prostacyclin.
LA, left atrial; PA, pulmonary artery.
Where LA pressure is stated this may also have been determined by pulmonary capillary wedge pressure assessment.