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. 2006 Apr 27;92(10):1457–1462. doi: 10.1136/hrt.2005.084715

Table 2 Predisposing conditions of patients in 326 episodes of infective endocarditis analysed together and separately in five‐year periods.

1980–2004 1980–4 1985–9 1990–4 1995–9 2000–4 p Value
No of episodes 326 61 45 65 60 95
Cardiac conditions 0.491*
 Acquired valvular disease 75 (23.0%) 17 (27.9%) 8 (17.8%) 15 (23.1%) 13 (21.7%) 22 (23.2%)
 Prosthetic valves 67 (20.6%) 14 (23.0%) 13 (28.9%) 14 (21.5%) 11 (18.3%) 15 (15.8%)
 Bicuspid aortic valve 38 (11.7%) 9 (14.8%) 6 (13.3%) 7 (10.8%) 6 (10.0%) 10 (10.5%)
 Mitral valve prolapse 33 (10.1%) 2 (3.3%) 4 (8.9%) 11 (16.9%) 7 (11.7%) 9 (9.5%)
 Congenital heart disease 10 (3.1%) 3 (4.9%) 2 (4.4%) 3 (4.6%) 0% 2 (2.1%)
 No underlying cardiac condition 103 (31.6%) 16 (26.2%) 12 (26.7%) 15 (23.1%) 23 (38.3%) 37 (39.0%)
Alcohol misuse 29 (8.9%) 5 (8.2%) 4 (8.9%) 7 (10.8%) 8 (13.3%) 5 (5.3%) 0.505
Intravenous drug use 25 (7.7%) 0% 0% 0% 6 (10.0%) 19 (20.0%) <0.001
Dialysis 10 (3.1%) 0% 0% 0% 3 (5.0%) 7 (7.4%) 0.015
Underlying diseases
 Diabetes 31 (9.5%) 2 (3.3%) 5 (11.1%) 9 (13.9%) 7 (11.7%) 8 (8.4%) 0.313
 Collagen disease 22 (6.8%) 6 (9.8%) 2 (4.4%) 3 (4.6%) 4 (6.7%) 7 (7.4%) 0.785
 Malignancy 15 (4.6%) 2 (3.3%) 0% 2 (3.1%) 2 (3.3%) 9 (9.5%) 0.078
Dental infections 107 (32.8%) 12 (19.7%) 17 (37.8%) 24 (36.9%) 17 (28.3%) 37 (38.9%) 0.244
Prior surgical procedures 51 (15.7%) 17 (27.9%) 5 (11.1%) 7 (10.8%) 7 (11.7%) 15 (15.8%) 0.085*
 Dental 29 (8.9%) 10 (16.4%) 2 (4.4%) 7 (10.8%) 2 (3.3%) 8 (8.4%)
 Urological 8 (2.5%) 3 (4.9%) 1 (2.2%) 0% 1 (1.7%) 3 (3.2%)
 Gastrointestinal 6 (1.8%) 0% 2 (4.4%) 0% 2 (3.3%) 2 (2.1%)
 Other 8 (2.5%) 4 (6.6%) 0% 0% 2 (3.3%) 2 (2.1%)

*p value for overall group differences.