Table 2 Predisposing conditions of patients in 326 episodes of infective endocarditis analysed together and separately in five‐year periods.
1980–2004 | 1980–4 | 1985–9 | 1990–4 | 1995–9 | 2000–4 | p Value | |
---|---|---|---|---|---|---|---|
No of episodes | 326 | 61 | 45 | 65 | 60 | 95 | |
Cardiac conditions | 0.491* | ||||||
Acquired valvular disease | 75 (23.0%) | 17 (27.9%) | 8 (17.8%) | 15 (23.1%) | 13 (21.7%) | 22 (23.2%) | |
Prosthetic valves | 67 (20.6%) | 14 (23.0%) | 13 (28.9%) | 14 (21.5%) | 11 (18.3%) | 15 (15.8%) | |
Bicuspid aortic valve | 38 (11.7%) | 9 (14.8%) | 6 (13.3%) | 7 (10.8%) | 6 (10.0%) | 10 (10.5%) | |
Mitral valve prolapse | 33 (10.1%) | 2 (3.3%) | 4 (8.9%) | 11 (16.9%) | 7 (11.7%) | 9 (9.5%) | |
Congenital heart disease | 10 (3.1%) | 3 (4.9%) | 2 (4.4%) | 3 (4.6%) | 0% | 2 (2.1%) | |
No underlying cardiac condition | 103 (31.6%) | 16 (26.2%) | 12 (26.7%) | 15 (23.1%) | 23 (38.3%) | 37 (39.0%) | |
Alcohol misuse | 29 (8.9%) | 5 (8.2%) | 4 (8.9%) | 7 (10.8%) | 8 (13.3%) | 5 (5.3%) | 0.505 |
Intravenous drug use | 25 (7.7%) | 0% | 0% | 0% | 6 (10.0%) | 19 (20.0%) | <0.001 |
Dialysis | 10 (3.1%) | 0% | 0% | 0% | 3 (5.0%) | 7 (7.4%) | 0.015 |
Underlying diseases | |||||||
Diabetes | 31 (9.5%) | 2 (3.3%) | 5 (11.1%) | 9 (13.9%) | 7 (11.7%) | 8 (8.4%) | 0.313 |
Collagen disease | 22 (6.8%) | 6 (9.8%) | 2 (4.4%) | 3 (4.6%) | 4 (6.7%) | 7 (7.4%) | 0.785 |
Malignancy | 15 (4.6%) | 2 (3.3%) | 0% | 2 (3.1%) | 2 (3.3%) | 9 (9.5%) | 0.078 |
Dental infections | 107 (32.8%) | 12 (19.7%) | 17 (37.8%) | 24 (36.9%) | 17 (28.3%) | 37 (38.9%) | 0.244 |
Prior surgical procedures | 51 (15.7%) | 17 (27.9%) | 5 (11.1%) | 7 (10.8%) | 7 (11.7%) | 15 (15.8%) | 0.085* |
Dental | 29 (8.9%) | 10 (16.4%) | 2 (4.4%) | 7 (10.8%) | 2 (3.3%) | 8 (8.4%) | |
Urological | 8 (2.5%) | 3 (4.9%) | 1 (2.2%) | 0% | 1 (1.7%) | 3 (3.2%) | |
Gastrointestinal | 6 (1.8%) | 0% | 2 (4.4%) | 0% | 2 (3.3%) | 2 (2.1%) | |
Other | 8 (2.5%) | 4 (6.6%) | 0% | 0% | 2 (3.3%) | 2 (2.1%) |
*p value for overall group differences.