Table 3 Comparison of changes in risk factors in standard and aggressively treated groups.

Variable	Treatment group	Baseline	Follow up	p Value*	Change	p Value†
Total cholesterol (mmol/l)	Standard	4.85 (1.14)	4.43 (1.1)	0.002	0.42 (0.13)	0.05
	Aggressive	4.96 (1.6)	4.1 (1.18)	<0.001	0.85 (0.17)
Triglyceride (mmol/l)	Standard	2.16 (2.58)	1.95 (1.54)	0.30	0.21 (0.2)	0.99
	Aggressive	2.22 (1.86)	2.01 (1.4)	0.23	0.2 (1.7)
HDL cholesterol (mmol/l)	Standard	1.11 (0.35)	1.23 (0.35)	0.002	−0.11 (0.03)	0.88
	Aggressive	1.09 (0.36)	1.2 (0.36)	<0.001	−0.11 (0.03)
LDL cholesterol (mmol/l)	Standard	2.79 (0.78)	2.34 (0.78)	<0.001	0.44 (0.1)	0.02
	Aggressive	2.82 (1.05)	1.98 (0.88)	<0.001	0.82 (0.12)
Homocysteine (μmol/l)	Standard	25.8 (14.4)	24.7 (11.0)	0.55	0.3 (1.9)	0.004
	Aggressive	25.9 (12.4)	19.0 (6.8)	<0.001	7.0 (1.3)
CRP (mg/l)	Standard	5.6 (1.4–8.0)	7.8 (3.1–15.0)	0.01	13.5 (7.6)	0.18
	Aggressive	6.0 (1.8–9.9)	6.5 (3.0–12.0)	0.001	3.2 (2.0)
Systolic BP (mm Hg)	Standard	142 (22)	143 (21)	0.89	0 (3)	0.1
	Aggressive	146 (21)	140 (21)	0.01	6 (2)
Diastolic BP (mm Hg)	Standard	81 (14)	80 (12)	0.45	1 (2)	0.07
	Aggressive	86 (12)	81 (12)	0.001	5 (1)
Haemoglobin (g/l)	Standard	109.2 (15.4)	111.5 (16.1)	0.38	−2.3 (2.6)	0.65
	Aggressive	109.7 (17.1)	110.5 (14.4)	0.71	−0.8 (2.1)
Phosphate (mmol/l)	Standard	1.7 (0.4)	1.8 (0.6)	0.17	−0.1 (0.1)	0.05
	Aggressive	1.8 (0.5)	1.7 (0.5)	0.15	0.1 (0.1)
Albumin (g/l)	Standard	38.2 (3.9)	37.2 (5.2)	0.1	1.0 (0.6)	0.07
	Aggressive	37.5 (5.1)	38.1 (4.8)	0.35	−0.5 (0.6)
Aspirin use	Standard	23 (32%)	17 (37%)	0.3	5%	<0.001
	Aggressive	40 (50%)	40 (76%)	<0.001	26%
Smoking	Standard	7 (10%)	2 (3%)	0.2	70%	0.02
	Aggressive	4 (5%)	0	NS	100%

Data expressed as mean (SD), median (interquartile range) or percentage.

*Baseline v follow up; †standard v aggressively treated groups.

BP, blood pressure; CRP, C reactive protein; HDL, high density lipoprotein; LDL, low density lipoprotein.