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. 1994 Jan;62(1):329–331. doi: 10.1128/iai.62.1.329-331.1994

An intestinal xenograft model for Cryptosporidium parvum infection.

J D Thulin 1, M S Kuhlenschmidt 1, M D Rolsma 1, W L Current 1, H B Gelberg 1
PMCID: PMC186107  PMID: 8262647

Abstract

Paired segments of near-term fetal rabbit small intestine were transplanted subcutaneously into athymic nude mice. At 5 weeks postsurgery, the xenografts were inoculated intraluminally with Cryptosporidium parvum sporozoites. Parasites rapidly and reliably infected the xenograft mucosal epithelium. Lesions typical of cryptosporidiosis were readily apparent by light microscopy and scanning and transmission electron microscopy. Xenografts are well suited to the study of the early events of C. parvum infection and are of potential value in the evaluation of anticryptosporidial chemotherapeutic agents.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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