Table 3 Effect of tirofiban and aspirin–clopidogrel combination on haemodynamic function.
| Group | HR (beats/min) | LVSP (mm Hg) | LVEDP (mm Hg) | +dp/dtmax (mm Hg/s) | −dp/dtmax (mm Hg/s) | CO (l/min) |
|---|---|---|---|---|---|---|
| Sham (n = 8) | ||||||
| Baseline | 110 (4) | 115 (5) | 3.9 (2.0) | 2900 (541) | 2612 (112) | 2.67 (0.12) |
| Control (n = 8) | ||||||
| Baseline | 109 (5) | 115 (4) | 4.0 (1.5) | 2850 (547) | 2538 (207) | 2.58 (0.36) |
| Ischaemia 3 h | 107 (6) | 100 (4)** | 7.1 (2.0)** | 2475 (468)* | 2275 (191)* | 1.26 (0.29)** |
| Reperfusion 1 h | 108 (6) | 109 (3)**‡ | 6.1 (1.6)** | 2287 (551)**‡ | 2112 (242)**‡ | 1.34 (0.25)** |
| Tirofiban (n = 8) | ||||||
| Baseline | 109 (8) | 116 (7) | 3.9 (2.6) | 2889 (453) | 2568 (189) | 2.49 (0.37) |
| Ischaemia 3 h | 108 (9) | 101 (5)** | 6.7 (2.3)** | 2456 (436)** | 2164 (159)** | 1.22 (0.26)** |
| Reperfusion 1 h | 107 (9) | 111 (2)*†‡ | 4.3 (1.9)**†‡ | 2759 (492)*†‡ | 2419 (183)*†‡ | 1.94 (0.31)**†‡ |
| Combination (n = 8) | ||||||
| Baseline | 108 (8) | 115 (6) | 3.9 (2.5) | 2775 (437) | 2589 (208) | 2.54 (0.47) |
| Ischaemia 3 h | 107 (9) | 102 (6)** | 6.9 (1.9)** | 2425 (306)* | 2290 (189)* | 1.27 (0.26)** |
| Reperfusion 1 h | 109 (9) | 108 (3)**‡ | 6.1 (2.1)** | 2268 (437)**‡ | 2098 (211)**‡ | 1.39 (0.28)** |
| IPC (n = 8) | ||||||
| Baseline | 110 (6) | 115 (3) | 3.8 (2.1) | 2950 (444) | 2450 (151) | 2.50 (0.30) |
| Ischaemia 3 h | 109 (5) | 100 (6)** | 6.6 (1.5)** | 2550 (469)** | 2200 (169)** | 1.23 (0.17)** |
| Reperfusion 1 h | 109 (5) | 111 (4)*†‡ | 4.8 (2.0)*†‡ | 2788 (470)*†‡ | 2337 (130)*†‡ | 1.91 (0.28)*†‡ |
Data are expressed as the mean (SD).
*p<0.05, **p<0.01 v baseline; †p<0.05 v control; ‡p<0.05 v ischaemia 3 h.
CO, cardiac output; ±dp/dtmax, maximum change rate of left ventricular pressure rise and fall; HR, heart rate; IPC ischaemic preconditioning; LVSP, left ventricular systolic pressure; LVEDP, left ventricular end diastolic pressure.