Table 1 Morphometric measurements.
| Parameter | WT‐sham (n = 9) | hKO‐sham (n = 9) | WT‐MI (n = 8)* | hKO‐MI (n = 9)* | p Value |
|---|---|---|---|---|---|
| Infarct size (%LV circumference) | – | – | 19.80 (0.99) | 20.94 (0.95) | NS |
| Lung wet:dry weight (mg/mg) | 4.69 (0.12) | 4.71 (0.11) | 4.60 (0.15) | 5.17 (0.13)†‡ | <0.05†; 0.01‡ |
| HW:BW (mg/g) | 6.50 (0.34) | 6.40 (0.30) | 7.17 (0.72) | 9.78 (0.91)†‡ | <0.01†; <0.05‡ |
| Fibrosis (pixels) | 0.31 (0.08) | 0.30 (0.13) | 21.09 (4.71)† | 26.42 (6.25)† | <0.001† |
| Myocyte size (μm) | 89.86 (2.06) | 89.83 (2.99) | 125.63 (1.91)† | 175.48 (4.48)†‡ | <0.001†‡ |
Values are mean (SE).
*Except for fibrosis, where n = 4 in wild type (WT) myocardial infarction (MI) and n = 5 in heterozygous knockout (hKO) ‐MI; †versus sham; ‡versus WT‐MI.
HW:BW, heart weight to body weight ratio; LV, left ventricular.