Table 1.

Recombination rates

Recombination rates r_i observed in the presence or absence of NCp7, in each interval i of the region of homology (the location of these intervals is given in Fig. 1). For each experimental condition (columns 3 to 7), standard errors on r_i were estimated as Δr_i = r_i[(n_i)^−1/2 + (N)^−1/2]. N, total number of recombinants cloned and analyzed in each independent experiment; n_i, number of recombinants occurring in the interval i. Separate experiments were pooled in each case. HIV-1, naked RNA, three experiments with N equal to 44, 49, and 33. RNA/NCp7, two experiments (54 and 35 clones). RNA/StpA, one experiment (58 clones). MoMLV, naked RNA, two experiments (49 and 43 clones). RNA/NCp7, two experiments (42 and 41 clones). σ, the standard deviation of the recombination rates estimated for each interval, n_i, with respect to their mean r̄ was calculated as

 

The weight w_i attributed to each interval was its relative size in nucleotides (given in column 2 of the Table).