Table 1 Stem cell trials.
| Trial | Randomised | Method of LVEF assessment | Length of follow up (months) | Group | Mean basal EF (%) | Mean final EF (%) | Change in EF | p Value |
|---|---|---|---|---|---|---|---|---|
| BOOST12 | Yes | MRI | 6 | Control, n = 30 | 51.3 | 52.0 | 0.7 | |
| Active, n = 30 | 50.0 | 56.7 | 6.7 | 0.026 | ||||
| MAGIC13 | Yes | SPECT and echo | 6 | Control, n = 1 | 33.0 | 39.0 | 6 | |
| Cells+ G‐CSF, n = 7 | 48.7 | 55.1 | 7 | 0.005 | ||||
| G‐CSF only, n = 3 | 45.4 | 44.0 | −1.5 | 0.007 | ||||
| TOPCARE‐AMI11 | No | LV angiography | 4 | Control , n = 11 | 51.0 | 53.5 | 2.5 | |
| Active, n = 19 | 51.6 | 60.1 | 8.5 | 0.003 | ||||
| Janssens et al16 | Yes | MRI and echo | 4 | Control, n = 34 | 46.9 | 49.1 | 2.2 | |
| Active, n = 32 | 48.5 | 51.8 | 3.4 | 0.36 | ||||
| ASTAMI20 | Yes | MRI | 6 | Control, n = 50 | 53.6 | 58.1 | 4.5 | |
| Active, n = 50 | 54.8 | 56.2 | 1.4 | 0.51 | ||||
| TCT STAMI | Yes | Echo | 6 | Control, n = 10 | 58.2 | 56.3 | −1.9 | |
| Active, n = 10 | 53.8 | 58.6 | 4.8 | <0.05 | ||||
| Observational studies | ||||||||
| Baks et al18 | NA | MRI | 5 | n = 22 | 48 | 55 | 7 | <0.05 |
| Ingkanisorn et al19 | NA | MRI | 2 | n = 33 | 52 | 57 | 5 | <0.002 |
EF, ejection fraction; G‐CSF, granulocyte‐colony stimulating factor; LVEF, left ventricular ejection fraction; MRI, magnetic resonance imaging; NA, not applicable; SPECT, single photon emission computed tomography.