Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Metabolism of all-trans-RA in transfected COS-1 cells. Conversion of all-trans-RA to water-soluble metabolites is observed in P450RAI-2- or P450RAI-1-expressing cells compared with pcDNA vector or media alone control samples (A). Fractions from HPLC chromatography were grouped into three regions (all-trans-RA substrate, 4-OH region, and polar region), which allowed quantification of the different classes of retinoid metabolites.
