Table 3 Performance indicators of nm23‐H1 as a marker of cervical intraepithelial neoplasia and high‐risk human papillomavirus type.

Outcome variable	Performance of nm23‐H1 (95% CI)*
	Sensitivity, %	Specificity, %	PPV, %	NPV, %
CIN†	48.8 (40.4 to 57.3)	90.0 (71.4 to 100)	98.5 (95.6 to 100)	11.5 (4.4 to 18.6)
CIN3‡	68.5 (62.5 to 74.6)	80.0 (68.9 to 91.1)	94.0 (90.4 to 97.6)	35.7 (26.8 to 44.5)
HR‐HPV	64.4 (57.7 to 71.1)	52.1 (40.4 to 63.7)	78.8 (72.6 to 85.2)	34.5 (25.6 to 43.5)

CIN, cervical intraepithelial neoplasia; HR‐HPV, high‐risk human papillomavirus; NPV, negative predictive value; PPV, positive predictive value.

*nm23‐H1 staining (reduced or strong).

^†Any grade of CIN (squamous cell carcinoma (SCC) cases excluded).

^‡CIN3 cut‐off (SCC cases included).