TABLE 1.
Inactivation parameters of fit
% not inactivated | % fast | τ fast (ms) | % intermediate | τ intermediate (ms) | % slow | τ slow (ms) | n | |||
---|---|---|---|---|---|---|---|---|---|---|
Recovery from 2-ms step | Fig. 1 | PKJ | 26 ± 2 | 67 ± 2 | 2.6 ± 0.2 | 7 ± 1 | 61 ± 13 | 11 | ||
CBN | 23 ± 2 | 56 ± 3 | 2.8 ± 0.4 | 21 ± 3 | 165 ± 24 | 10 | ||||
Fig. 3 | PKJ WT | 26 ± 2 | 67 ± 2 | 3.4 ± 1.1 | 7 ± 1 | 79 ± 12 | 21 | |||
PKJ med | 17 ± 1 | 78 ± 1 | 2.7 ± 0.1 | 5 ± 0.3 | 115 ± 17 | 7 | ||||
CBN WT | 26 ± 2 | 56 ± 2 | 2.3 ± 0.2 | 18 ± 2 | 208 ± 27 | 21 | ||||
CBN med | 30 ± 3 | 57 ± 2 | 1.7 ± 0.1 | 13 ± 1 | 191 ± 36 | 8 | ||||
Recovery from 500-ms step | Fig. 1 | PKJ | 2 ± 1 | 20 ± 5 | 4.3 ± 0.7 | 38 ± 8 | 123.0 ± 28.9 | 40 ± 10 | 948 ± 210 | 8 |
CBN | 4 ± 1 | 12 ± 1 | 10.4 ± 2.3 | 57 ± 7 | 231.0 ± 21 | 27 ± 7 | 3857 ± 2074 | 9 | ||
Fig. 3 | PKJ WT | 3 ± 1 | 19 ± 3 | 4.8 ± 0.9 | 41 ± 6 | 132.8 ± 20 | 37 ± 6 | 1260 ± 397 | 13 | |
PKJ med | 1 ± 1 | 15 ± 2 | 6.1 ± 0.9 | 49 ± 9 | 188.5 ± 37 | 35 ± 9 | 1739 ± 1009 | 7 | ||
CBN WT | 4 ± 1 | 14 ± 1 | 7.9 ± 1.4 | 60 ± 3 | 208.5 ± 22 | 22 ± 3 | 2124 ± 643 | 17 | ||
CBN med | 3 ± 1 | 11 ± 2 | 4.4 ± 0.4 | 49 ± 9 | 113.3 ± 28 | 37 ± 8 | 1942 ± 1328 | 5 | ||
Entry into slow inactivation | Fig. 1 | PKJ | 26 ± 5 | 51 ± 2 | 80.3 ± 3.4 | 23 ± 3 | 1284 ± 481 | 7 | ||
CBN | 35 ± 4 | 36 ± 6 | 70.5 ± 19 | 29 ± 6 | 759 ± 146 | 7 | ||||
Fig. 3 | PKJ WT | 28 ± 2 | 49 ± 2 | 85.4 ± 4.7 | 23 ± 1 | 1705 ± 212 | 12 | |||
PKJ med | 29 ± 1 | 52 ± 2 | 80.2 ± 7.8 | 19 ± 2 | 1143 ± 181 | 8 | ||||
CBN WT | 33 ± 2 | 36 ± 3 | 73.1 ± 13.5 | 31 ± 2 | 1555 ± 255 | 16 | ||||
CBN med | 31 ± 4 | 43 ± 3 | 79.7 ± 4.8 | 26 ± 3 | 1840 ± 102 | 5 |