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. Author manuscript; available in PMC: 2008 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2006 Nov 10;15(3):1298–1310. doi: 10.1016/j.bmc.2006.11.010

Figure 2.

Figure 2

This figure shows the amino acids (carbon is white, nitrogen is blue, oxygen is red, chlorine is green, and sulfur is yellow) interacting with SK&F 64139 (6) at the active site of hPNMT.22, 48 A Connolly (solvent accessible) surface exposing 6 is shown and a lipophilic potential is mapped on the Connolly surface whereby the areas shown in green are neutral, blue are hydrophilic, and brown are lipophilic. The brown lipophilic region of the Connolly surface adjacent to Val53, Met258, Val272, and Val269 is not easily observed, as it is perpendicular to the plane of the page. Hydrogens are not shown for clarity.