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. Author manuscript; available in PMC: 2007 May 2.
Published in final edited form as: Cancer Res. 2005 May 1;65(9):3883–3893. doi: 10.1158/0008-5472.CAN-04-3757

Figure 3.

Figure 3

Lonafarnib and paclitaxel synergistically increase acetylated tubulin, mitotic arrest, and apoptosis. A, flow cytometry was done with an acetylated tubulin antibody in A549 cells treated with the indicated drugs. Representation of acetylated tubulin levels after 16 hours of drug treatment. Columns, mean fluorescence for acetylated tubulin relative to that of control untreated cells (FTI: lonafarnib). B, acetylated tubulin immunofluorescence of cells treated with lonafarnib and paclitaxel, both alone and in combination, for 16 and 32 hours. C, cell cycle analysis for 16 and 32 hours of treatment with the combination of lonafarnib and paclitaxel.