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The synergistic increase in acetylated tubulin caused by lonafarnib and paclitaxel treatment correlates with FT inhibition and mitotic arrest. A, Western blot analysis for acetylated tubulin, HDJ-2 (N, non-farnesylated band; F, farnesylated band), and total tubulin following lonafarnib and/or paclitaxel treatment over time. B, percent mitosis assessed by DNA staining, done in parallel and with the same drug treatments over time as in A. Bars, SD.
