Table 1.

Analysis of in vivo microtubule dynamics in the presence and absence of lonafarnib

Parameter	Control	Lonafarnib 10 − mol/L	Percent change
Growth
Rate (− m/min)	11.2 ± 2.1	7.7 ± 3.8	−31%
Length (− m)	2.9 ± 1.6	1.9 ± 0.9	−34%
Time (min)	0.3 ± 0.08	0.28 ± 0.07	−7%
Shortening
Rate (− m/min)	17.1 ± 4.0	9.9 ± 3.3	−41%
Length (− m)	5.3 ± 1.9	3.1 ± 1.6	−42%
Time (min)	0.34 ± 0.11	0.33 ± 0.1	−3%
Pause
Time (min)	0.36 ± 0.23	0.40 ± 0.2	−11%
Percentage time spent
Growth	30	17
Shortening	17	8.8
Pause	53	74.2
Dynamicity (− m/min)	8.1 ± 4.0	3.0 ± 1.9	−63%
Rescue frequency (events/min)	4.1 ± 2.6	4.0 ± 2.5	−2%
Catastrophe frequency (events/min)	0.9 ± 0.8	0.88 ± 0.75	−2%
Rescue frequency (events/− m)	0.19 ± 0.15	0.25 ± 0.21	31%
Catastrophe frequency (events/− m)	0.33 ± 0.29	0.37 ± 0.31	12%
Number of cells	21	23
Number of microtubules	81	69

NOTE: Values in boldface differ significantly from control values at >99% confidence interval as determined by Student’st test. Values are mean ± SD.