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. Author manuscript; available in PMC: 2008 Mar 15.
Published in final edited form as: Virology. 2006 Oct 20;359(2):349–361. doi: 10.1016/j.virol.2006.09.020

Figure 6. Murine BMDC previously matured with LPS and infected with VV-gp33-41 are capable of activating naïve P14 gp33-41-specific CD8+ T cells.

Figure 6

Mouse BMDC were treated with LPS (L) for 18 hours followed by pulsing with 10−10M gp33-41, infection with VV-gp33-41, or exposure to UV VV-gp33-41 for 12 hours. Virus treatments were performed with MOIs of 0.1, 1, and 10. Treated BMDC were co-cultured for 3 days with CFSE-labeled splenocytes from naïve gp33-41-specific P14 TCR transgenic mice. A, Percent of gp33-41-specific CD8+ T cells that entered division. B, Percent of P14 T cells that produced IFNγ+ following restimulation at the end of the three day co-culture period. Values are the average of 3 experiments.