Table 1.

FAH AND CORE ANTIGEN NEGATIVE FOCI IN CHRONICALLY INFECTED WOODCHUCKS^*

Woodchuck	Age (mo.)	FAH			Core neg. (not FAH)	Hepatocytes per section
		Basophilic	Amphophilic	Clear cell
307	15				1	14,000
	19				1(f+)	17,000
	26		1	1		17,000
309	12			2(f+)		35,000
	15				2(f+)	45,000
	19		1(f−)			34,000
310	9				2(f+)	22,000
	15				1(f+)	26,000
	26		2(f−)	1(f+)	1(f+)	50,000
313	12				no foci	24,000
	15		2(f−)			19,000
	19				no foci	11,000
314	9				no foci	20,000
	12				no foci	18,000
	15				no foci	12,000
	19	1				26,000
	26				no foci	11,000
359	14				1(f+)	24,000
366	14	1(f−)				32,000
371	14				1(f+)	18,000
4961	15				no foci	53,000
	19				3(f+)	64,000
	26		1	1(f+)		26,000
501	40(au)	1(f−)				82,000
5114	15	1(f−)			1(f+)	40,000
5154	15				no foci	23,000
	19				1(f+)	28,000
	28(au)				15(f+)	194,000
3202	(au)	1	1		1	549,000
Totals		4	8	5	31

^*The number and types of FAH detected in biopsy and autopsy (au) samples from chronically WHV infected woodchucks. Selected liver samples were tested for fetuin protein expression by immunoperoxidase staining and are characterized as either f+ or f−. The former yielded a similar level of fetuin protein as the hepatocytes in the surrounding liver, while the latter showed reduced or undetectable staining. All FAH were negative for WHV core antigen expression. The right hand column lists the approximate number of hepatocytes in each tissue section scored.