Table 4.
One-way Sensitivity Analyses: Incremental Cost-effectiveness Ratios
| Variable | Cost Per Life-Year Gained: 3-D CT Colonography (CTC) Every 5 yr* | Cost Per Life-Year Gained: 3-D CT Colonography (CTC) Every 10 Yr* |
|---|---|---|
| Base case | $156,000 | $7,840 |
| Cost of CT colonography | ||
| $200 | CTC dominant | $57,410 |
| $400 | CTC dominant | $29,750 |
| $600 | $198,140 | $2,100 |
| $800 | $401,100 | Optical colonoscopy dominant |
| $1,000 | $603,970 | Optical colonoscopy dominant |
| Cost of optical colonoscopy | ||
| $200 | $421,330 | Optical colonoscopy dominant |
| $400 | $304,120 | Optical colonoscopy dominant |
| $600 | $186,920 | Optical colonoscopy dominant |
| $800 | $69,720 | $30,450 |
| $1000 | CTC dominant | $61,160 |
| $1200 | CTC dominant | $91,870 |
| Adherence with initial screening test | ||
| 20% | $20,150 | $1,060 |
| 40% | $48,900 | $3,510 |
| 60% | $156,000 | $7,840 |
| 80% | Optical colonoscopy dominant | $13,640 |
| 100% | Optical colonoscopy dominant | $21,610 |
| Adherence with follow-up optical colonoscopy | ||
| 25% | Optical colonoscopy dominant | Optical colonoscopy dominant |
| 50% | Optical colonoscopy dominant | Optical colonoscopy dominant |
| 75% | $156,000 | $7,840 |
| 95% | $33,210 | $107,530 |
| Sensitivity of CT colonography for 1 cm adenomas | ||
| 60% | Optical colonoscopy dominant | Optical colonoscopy dominant |
| 70% | Optical colonoscopy dominant | Optical colonoscopy dominant |
| 80% | Optical colonoscopy dominant | $1,870 |
| 90% | $175,580 | $7,120 |
| 95% | $102,160 | $10,950 |
| 99% | $73,990 | $14,690 |
*
Bold print means that CT colonography is the more effective test; italics that optical colonoscopy every 10 yr is the more effective test. Dollar figures are incremental cost per life-year gained of the more versus less effective test. All costs and life expectancy discounted at 3%.