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Activation of PKA holoenzyme containing Cα2. A cIMP activation curve for the PKA holoenzyme containing Cα2 and RIIα (as found in wild-type mouse sperm) is compared with that obtained for a Cα2/RIα holoenzyme [as found in sperm from mice with a targeted disruption of the RIIα gene (RIIα KO)]. Results are the average of triplicate data points. Error bars for SD are shown.
