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. 2002 May 15;16(10):1195–1208. doi: 10.1101/gad.221402

Figure 3.

Figure 3

The cdc13-245 mutation impairs an end-processing pathway that is redundant with Rad50. (A) The cdc13-245 mutation increases the IR sensitivity of rad50-d cells. (B) Indirect immunofluorescence microscopy of wild-type cells and the indicated mutant strains at 1 h postirradiation (500 Gy). A cross-reacting human anti-Rad51 antibody was used to detect Rhp51. Note that rad54-d cdc13-245 cells are proficient in the formation of Rhp51 foci, but a rad50-d cdc13-245 double mutant is impaired. (C) Mean percentage of various mutant cells showing Rhp51 foci at 1 h postirradiation.