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. 2002 May 15;16(10):1195–1208. doi: 10.1101/gad.221402

Figure 7.

Figure 7

A model indicating two functions for Cdc2–cyclin B kinase in HR. (Left panel) Cdc2–cyclin B kinase activity positively regulates an early step in HR that is redundant with Rad50. Both steps generate recombination intermediates that are processed by Rqh1 DNA helicase in association with topoisomerase III. Cdc2–cyclin B kinase activity exerts a second function together with Crb2 at a late step in HR. Both proteins are required to maintain Top3 activity until all recombination intermediates are processed. Cdc2–Cdc13 kinase activity may prevent premature dephosphorylation of Crb2, thereby supporting Top3 function. In the absence of Top3 activity, Rqh1 uses an alternative pathway resulting in hyperrecombination. (Right panel) Probable defects associated with the cdc13-245 mutation.