Figure 1.
The 0.7-kb ANF regulatory region is responsible for the developmental pattern of the endogenous ANF gene. (A) A lateral view of the endogenous ANF gene expression in the heart of E9.5 mouse embryo. (B,C) A lateral view of the nlacZ reporter gene expression in the heart of E9.5 transgenic embryos. (D,F) A ventral (D) and dorsal (F) view of the endogenous ANF expression at E11.5. (E,G) A ventral (E) and dorsal (G) view of ANF transgene expression at E11.5. (ift) Inflow tract; (la) left atrium; (ra) right atrium; (avc) atrioventricular canal; (lv) left ventricle; (rv) right ventricle; (oft) outflow tract; (lscv) left superior caval vein; (rscv) right superior caval vein; (as) aortic sac.
