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. Author manuscript; available in PMC: 2008 Apr 1.
Published in final edited form as: Dev Biol. 2006 Dec 21;304(1):272–285. doi: 10.1016/j.ydbio.2006.12.033

Figure 8.

Figure 8

Overexpression of truncated FGFR1 causes reduced proliferation in neural retinal cells by embryonic day 4.(A) Infection at stage 11 with a retrovirus overexpressing a kinase domain truncation of FGFR1 and co-expressing LacZ (pZid: LacZ+DN FR1). Infected cells (blue:Xgal) in the nasal compartment were found as isolated cells or as groups of two (arrows), as seen by examining isolated clones in several adjacent sections (sections are 10μm each, higher magnification views revealed that at 10μm there was a single blue cell and at 30 μm there were a pair of blue cells). (B) In cells infected with control virus overexpressing only the LacZ gene (pZid: LacZ), infected cells give rise to progeny that demonstrated well-characterized clonal growth pattern in the nasal compartment. (C) Likewise, control virus overexpressing the LacZ gene and a full length version of the FGFR1 (pZid: LacZ+FL FR1) gave rise to infected cells that proliferate and extend radially.