Abstract
Developments of the past decade have greatly improved the likelihood that patients can control their asthma. Inhaled medications are basic to a regimen that may include bronchodilators only, or bronchodilators along with cromoglycate and steroid to the extent required to achieve and maintain control. The regimen is modified for the individual and designed to control symptoms while avoiding an overdose of any one agent and overuse of inhaled bronchodilators (a sign of their lessening effectiveness). The regimen outlined emphasizes controlling asthma day to day and providing effective intervention early to prevent attacks from becoming severe.
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- Altounyan R. E., Howell J. B. Treatment of asthma with disodium cromoglycate (FPL 670, 'Intal'). Respiration. 1969;26(Suppl):131–140. doi: 10.1159/000192647. [DOI] [PubMed] [Google Scholar]
- Anderson S. D., Seale J. P., Rozea P., Bandler L., Theobald G., Lindsay D. A. Inhaled and oral salbutamol in exercise-induced asthma. Am Rev Respir Dis. 1976 Sep;114(3):493–500. doi: 10.1164/arrd.1976.114.3.493. [DOI] [PubMed] [Google Scholar]
- Arlian L. G., Brandt R. L., Bernstein R. Occurrence of house dust mites, Dermatophagoides spp. (Acari: Pyroglyphidae), during the heating season. J Med Entomol. 1978 Nov 7;15(1):35–42. doi: 10.1093/jmedent/15.1.35. [DOI] [PubMed] [Google Scholar]
- Bell T., Bigley J. Sustained-release theophylline therapy for chronic childhood asthma. Pediatrics. 1978 Sep;62(3):352–358. [PubMed] [Google Scholar]
- Blair H. Natural history of wheezing in childhood. J R Soc Med. 1979 Jan;72(1):42–48. doi: 10.1177/014107687907200113. [DOI] [PubMed] [Google Scholar]
- Boushey H. A., Holtzman M. J., Sheller J. R., Nadel J. A. Bronchial hyperreactivity. Am Rev Respir Dis. 1980 Feb;121(2):389–413. doi: 10.1164/arrd.1980.121.2.389. [DOI] [PubMed] [Google Scholar]
- Burr M. L., St Leger A. S., Neale E. Anti-mite measurements in mite-sensitive adult asthma. A controlled trial. Lancet. 1976 Feb 14;1(7955):333–335. doi: 10.1016/s0140-6736(76)90086-6. [DOI] [PubMed] [Google Scholar]
- Chan-Yeung M., Grzybowski S. Occupational asthma. Can Med Assoc J. 1976 Mar 6;114(5):433–436. [PMC free article] [PubMed] [Google Scholar]
- Chang K. C., Bell T. D., Lauer B. A., Chai H. Altered theophylline pharmacokinetics during acute respiratory viral illness. Lancet. 1978 May 27;1(8074):1132–1133. doi: 10.1016/S0140-6736(78)90305-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clark R. A., Anderson P. B. Combined therapy with salbutamol and beclomethasone inhalers in chronic asthma. Lancet. 1978 Jul 8;2(8080):70–72. doi: 10.1016/s0140-6736(78)91382-x. [DOI] [PubMed] [Google Scholar]
- Cockcroft D. W., Cartier A., Jones G., Tarlo S. M., Dolovich J., Hargreave F. E. Asthma caused by occupational exposure to a furan-based binder system. J Allergy Clin Immunol. 1980 Dec;66(6):458–463. doi: 10.1016/0091-6749(80)90006-8. [DOI] [PubMed] [Google Scholar]
- Cockcroft D. W., Ruffin R. E., Dolovich J., Hargreave F. E. Allergen-induced increase in non-allergic bronchial reactivity. Clin Allergy. 1977 Nov;7(6):503–513. doi: 10.1111/j.1365-2222.1977.tb01481.x. [DOI] [PubMed] [Google Scholar]
- Collins-Williams C., Chiu A. W., Lamenza C., Lewis-McKinley C. A., Williams H., Levison H. Treatment of bronchial asthma with disodium cromoglycate (Intal) in children. Ann Allergy. 1971 Dec;29(12):613–620. [PubMed] [Google Scholar]
- Corrao W. M., Braman S. S., Irwin R. S. Chronic cough as the sole presenting manifestation of bronchial asthma. N Engl J Med. 1979 Mar 22;300(12):633–637. doi: 10.1056/NEJM197903223001201. [DOI] [PubMed] [Google Scholar]
- Davis B., Gett P. M., Jones E. S. A service for the adult asthmatic. Thorax. 1980 Feb;35(2):111–113. doi: 10.1136/thx.35.2.111. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ellul-Micallef R., Fenech F. F. Effect of intravenous prednisolone in asthmatics with diminished adrenergic responsiveness. Lancet. 1975 Dec 27;2(7948):1269–1271. doi: 10.1016/s0140-6736(75)90608-x. [DOI] [PubMed] [Google Scholar]
- Epstein S. W., Manning C. P., Ashley M. J., Corey P. N. Survey of the clinical use of pressurized aerosol inhalers. Can Med Assoc J. 1979 Apr 7;120(7):813–816. [PMC free article] [PubMed] [Google Scholar]
- Farrell B. P., Kerr H. D., Kulle T. J., Sauder L. R., Young J. L. Adaptation in human subjects to the effects of inhaled ozone after repeated exposure. Am Rev Respir Dis. 1979 May;119(5):725–730. doi: 10.1164/arrd.1979.119.5.725. [DOI] [PubMed] [Google Scholar]
- Gandevia B. The changing pattern of mortality from asthma in Australia. 2. Mortality and modern therapy. Med J Aust. 1968 May 25;1(21):884–891. [PubMed] [Google Scholar]
- Hendeles L., Weinberger M., Wyatt R. Guide to oral theophylline therapy for the treatment of chronic asthma. Am J Dis Child. 1978 Sep;132(9):876–880. [PubMed] [Google Scholar]
- Holgate S. T., Baldwin C. J., Tattersfield A. E. beta-adrenergic agonist resistance in normal human airways. Lancet. 1977 Aug 20;2(8034):375–377. doi: 10.1016/s0140-6736(77)90304-x. [DOI] [PubMed] [Google Scholar]
- Lam S., Wong R., Yeung M. Nonspecific bronchial reactivity in occupational asthma. J Allergy Clin Immunol. 1979 Jan;63(1):28–34. doi: 10.1016/0091-6749(79)90158-1. [DOI] [PubMed] [Google Scholar]
- Larsson S., Svedmyr N. Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol in asthmatics. Am Rev Respir Dis. 1977 Nov;116(5):861–869. doi: 10.1164/arrd.1977.116.5.861. [DOI] [PubMed] [Google Scholar]
- McFadden E. R., Jr Exertional dyspnea and cough as preludes to acute attacks of bronchial asthma. N Engl J Med. 1975 Mar 13;292(11):555–559. doi: 10.1056/NEJM197503132921103. [DOI] [PubMed] [Google Scholar]
- Morris H. G. Drug-induced desensitization of beta adrenergic receptors. J Allergy Clin Immunol. 1980 Feb;65(2):83–86. doi: 10.1016/0091-6749(80)90190-6. [DOI] [PubMed] [Google Scholar]
- Newman Taylor A. J. Occupational asthma. Thorax. 1980 Apr;35(4):241–245. doi: 10.1136/thx.35.4.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Orehek J., Charpin D., Velardocchio J. M., Grimaud C. Bronchomotor effect of bronchoconstriction-induced deep inspirations in asthmatics. Am Rev Respir Dis. 1980 Feb;121(2):297–305. doi: 10.1164/arrd.1980.121.2.297. [DOI] [PubMed] [Google Scholar]
- Pepys J., Hutchcroft B. J. Bronchial provocation tests in etiologic diagnosis and analysis of asthma. Am Rev Respir Dis. 1975 Dec;112(6):829–859. doi: 10.1164/arrd.1975.112.6.829. [DOI] [PubMed] [Google Scholar]
- Pierson W. E., Bierman C. W., Kelley V. C. A double-blind trial of corticosteroid therapy in status asthmaticus. Pediatrics. 1974 Sep;54(3):282–288. [PubMed] [Google Scholar]
- Powles A. C. The bronchodilator effect of fenoterol (Berotec). N Z Med J. 1975 Mar 12;81(535):249–251. [PubMed] [Google Scholar]
- Rebuck A. S., Read J. Assessment and management of severe asthma. Am J Med. 1971 Dec;51(6):788–798. doi: 10.1016/0002-9343(71)90307-x. [DOI] [PubMed] [Google Scholar]
- Resar R. K., Walson P. D., Fritz W. L., Perry D. F., Barbee R. A. Kinetics of theophylline; variability and effect of arterial pH in chronic obstructive lung disease. Chest. 1979 Jul;76(1):11–16. doi: 10.1378/chest.76.1.11. [DOI] [PubMed] [Google Scholar]
- Sarsfield J. K., Gowland G., Toy R., Norman A. L. Mite-sensitive asthma of childhood. Trial of avoidance measures. Arch Dis Child. 1974 Sep;49(9):716–721. doi: 10.1136/adc.49.9.716. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith J. M., Devey G. F. Clinical trial of disodium cromoglycate in treatment of asthma in children. Br Med J. 1968 May 11;2(5601):340–344. doi: 10.1136/bmj.2.5601.340. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Solomon W. R., Burge H. A., Boise J. R. Exclusion of particulate allergens by window air conditioners. J Allergy Clin Immunol. 1980 Apr;65(4):305–308. doi: 10.1016/0091-6749(80)90160-8. [DOI] [PubMed] [Google Scholar]
- Speizer F. E., Doll R. A century of asthma deaths in young people. Br Med J. 1968 Jul 27;3(5612):245–246. doi: 10.1136/bmj.3.5612.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tai E., Read J. Response of blood gas tensions to aminophylline and isoprenaline in patients with asthma. Thorax. 1967 Nov;22(6):543–549. doi: 10.1136/thx.22.6.543. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thiringer G., Svedmyr N. Comparison of infused and inhaled terbutaline in patients with asthma. Scand J Respir Dis. 1976;57(1):17–24. [PubMed] [Google Scholar]
- Toogood J. H., Jennings B., Greenway R. W., Chuang L. Candidiasis and dysphonia complicating beclomethasone treatment of asthma. J Allergy Clin Immunol. 1980 Feb;65(2):145–153. doi: 10.1016/0091-6749(80)90200-6. [DOI] [PubMed] [Google Scholar]
- Weinberger M. M., Bronsky E. A. Evaluation of oral bronchodilator therapy in asthmatic children. Bronchodilators in asthmatic children. J Pediatr. 1974 Mar;84(3):421–427. doi: 10.1016/s0022-3476(74)80732-8. [DOI] [PubMed] [Google Scholar]
- Wolfe J. D., Tashkin D. P., Calvarese B., Simmons M. Bronchodilator effects of terbutaline and aminophylline alone and in combination in asthmatic patients. N Engl J Med. 1978 Feb 16;298(7):363–367. doi: 10.1056/NEJM197802162980703. [DOI] [PubMed] [Google Scholar]
- Wyatt R., Waschek J., Weinberger M., Sherman B. Effects of inhaled beclomethasone dipropionate and alternate-day prednisone on pituitary-adrenal function in children with chronic asthma. N Engl J Med. 1978 Dec 21;299(25):1387–1392. doi: 10.1056/NEJM197812212992504. [DOI] [PubMed] [Google Scholar]