Table 1.
Binding of gp130(750–764) phosphopeptide analogues
| Peptide | IC50, nM | IC50 analogue/ IC50 wild type |
|---|---|---|
| STASTVE(pY)STVVHSG | 110 | |
| STASTVE(pY)ATVVHSG | 72 | 0.65 |
| STASTVE(pY)SAVVHSG | 110 | 1.0 |
| STASTVE(pY)STAVHSG | 3,400 | 31 |
| STASTVE(pY)STVAHSG | 1,100 | 10 |
| STASTVE(pY)STVVASG | 770 | 7.0 |
| STASTVE Y STVVHSG | 2.1 × 106 | 19,000 |
| STASTVE(pY)STVVHS | 61 | 0.55 |
| STASTVE(pY)STVVH | 77 | 0.70 |
| STASTVE(pY)STVV | 1,100 | 10 |
| Ac-TVE(pY)STVVHSG | 120 | 1.1 |
| Ac-VE(pY)STVVHSG | 110 | 1.0 |
| Ac-E(pY)STVVHSG | 970 | 8.8 |
| Ac-(pY)STVVHSG | 9,600 | 87 |
| Ac-AE(pY)STVVHSG | 580 | 5.3 |
| Ac-VA(pY)STVVHSG | 550 | 5.0 |
Ac, acetyl; pY, phosphotyrosine.