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. 2007 Feb 26;402(Pt 3):537–549. doi: 10.1042/BJ20060756

Figure 2. Internalized growth factor following a 10 nM bolus of EGF (diamonds), TGFα (squares), E40A (triangles) and Y13G (circles) for wild-type (A) and internalization impaired (B) EGFR.

Figure 2

Total number of intracellular growth factor (closed symbols) is contrasted with the number of bound intracellular growth factor molecules (open symbols) and Eqn 11 (dashed lines) for each of the EGFR ligands. Simulations used the parameter values listed in Tables 1 and 2. The percentage of bound ligand is listed next to the corresponding internalization curves.