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. 2007 Feb 26;402(Pt 3):537–549. doi: 10.1042/BJ20060756

Figure 8. Trafficking kinetics at maximal endosomal volume.

Figure 8

Dashed lines, eqns (30–32) specialized for the square root regime (zone V; Table 3) are contrasted with the corresponding simulations of the full model for a range of (180 min) pre-incubation concentrations of labelled EGF (left-hand panels) or TGFα (right-hand panels): 0.1 nM (light grey triangles), 1.0 nM (grey triangles) and 10 nM (black triangles). Parameter values are as in Tables 1 and 2, except for the endosomal volume, which is set at 2×10−13 litres/cell. (A and D) Intact extracellular ligand, (B and E) degraded extracellular ligand and (C and F) total endosomal ligand.