Table 1. Constitutive trafficking parameters for EGFR.

Constitutive trafficking parameters for EGFR transfected into B82 fibroblasts [23,26,35] and four ligands: EGF, TGFα and the EGF analogs E40A and Y13G [35].

(a) Surface parameters
Parameter	Meaning	Baseline value
ke*	Endocytosis rate constant	0.165 min−1
kt†	Constitutive internalization rate constant	0.030 min−1
n	Cell density	108 cells/l
Rs0†	Surface receptor number	118576/cell
(b) Endosomal parameters
Parameter	Meaning	Baseline value
khr†	Receptor degradation rate constant	0.0022 min−1
khl†	Ligand degradation rate constant	0.010 min−1
kx†	Receptor recycling	0.058 min−1
ksyn†	Receptor synthesis rate	130 receptors/cell min−1
Ve†	Total endosomal volume	10−14litres/cell
Ri0†	Endosomal receptor number	59091/cell

*Average estimates for B82 fibroblasts [23].

†Published estimates for B82 fibroblasts [26].