Figure 7.

Parp^CH1 and Sir2⁰⁵³²⁷ have opposite dominant effects on the variegated expression of GAL4/UAS constructs. The variegated expression of an Arm-Gal4-driven UAS-Tim17B -DsRed construct (A,B) or a UAS-Sir2-DsRed construct (D–E) is modified by background genotype. In a Parp^CH1/+ background (A,D), expression is strongly reduced compared to expression in a wild-type background (B,E). Similar variegated expression of the same constructs driven by 69B-GAL4 is almost completely suppressed in a Sir2⁰⁵³²⁷/+ background (C,F). Green: DNA.