FIGURE 1.

(A) Exponential (solid) and Gaussian functions with γ = −1.5 (dashed) indicating the attractive nonpolar term, and γ = −3 (dotted) indicating the repulsive generalized Born term. (B) Calculated insertion energy of the L_nA_(19−n) set of designed peptides together with the experimental best-fit line (E_Insertion = −0.66n_Leu + 2.14). The experimental error is estimated at ±0.2–0.3 kcal/mol (36). Sequences of the symmetrical peptides used for residue-pair scans are shown below the graph. Results for the positional dependency of the insertion energy as determined by symmetrical scans of leucine pairs are shown as points in the graph. Results for the remaining scans are given in Fig. 4.