FIGURE 6.

Insertion energy landscape of a helix as a function of the tilt angle and center of mass position along the membrane normal for optimized rotation angle (around the long axis of the helix). The profile for the acetylcholine receptor helix M2 (1a11, model 1) is representative of all transmembrane helices investigated, displaying four distinct minima, whereas the profile for magainin (2mag, model 1) is typical of all the other antimicrobial peptides analyzed in this study with two surface-bound energy minima. The potential zero was chosen to be at an infinite distance from the membrane.