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Dependence of activation and deactivation of P2X7 receptors on agonist concentration. (A, B) The mean time constants ± SD for fast activation and deactivation correspond to the approximations of Fig. 8. (dotted lines) [ATP4−] dependences of the time constants predicted by the C-C-C-O model (Eq. 8). (C) The time course of activation and deactivation of P2X7-dependent channels as predicted by the C-C-C-O model (Eq. 8) was fitted by monoexponentially relaxing functions (Eqs. 9 and 10).
