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Comparison of the behavior of repetitive (left) and heterogeneous (right) DNA sequences under an externally applied force. Repetitive DNA sequences can form bulge loops. These bulge loops can propagate to the other end of the DNA duplex and therefore cause a lengthening of the molecule. In contrast, this dissociation path is not available for heterogeneous DNA sequences. Heterogeneous DNA sequences simply dissociate in an all or none mode.
