TABLE 1.
Physiological parameters for perfused heart
| LVDP (mmHg) | HR (min−1) | RPP (mmHg min−1 × 103) | MVO2 (μmol min−1 g−1 dwt) | PCr (%) | ATP (%) | PCr/ATP ratio | pH | n | |
|---|---|---|---|---|---|---|---|---|---|
| 22°C | |||||||||
| Control | 150.9 ± 7.2 | 72.3 ± 2.6 | 10.9 ± 0.4 | 14.1 ± 0.6 | 100 | 100 | 1.75 ± 0.04 | 7.18 ± 0.03 | 6 |
| K+ Arrest | n/a | 0 | 0 | 5.0 ± 0.4* | 120.6 ± 4.3* | 95.4 ± 1.6 | 2.28 ± 0.10 | 7.22 ± 0.02 | 6 |
| Reperfusion | 148.9 ± 8.4 | 71.0 ± 4.6 | 10.5 ± 0.7 | 14.6 ± 1.0 | 93.2 ± 3.2 | 93.9 ± 1.3 | 1.75 ± 0.12 | 7.19 ± 0.03 | 6 |
| 30°C | |||||||||
| Control | 133.4 ± 7.8 | 173.1 ± 11.3 | 22.8 ± 1.5 | 20.1 ± 26 | 100 | 100 | 1.37 ± 0.11 | 7.19 ± 0.00 | 5 |
| K+ Arrest | n/a | 0 | 0 | 4.3 ± 0.6* | 106.2 ± 2.6* | 101.2 ± 1.8 | 1.43 ± 0.09 | 7.20 ± 0.00 | 5 |
| Reperfusion | 134.8 ± 9.4 | 177.8 ± 12.1 | 23.5 ± 1.7 | 21.4 ± 2.5 | 88.5 ± 3.8* | 96.9 ± 3.7 | 1.24 ± 0.05 | 7.19 ± 0.01 | 5 |
| 35°C | |||||||||
| Control | 118.3 ± 5.0 | 231.5 ± 7.69 | 27.5 ± 1.7 | 26.8 ± 2.0 | 100 | 100 | 1.39 ± 0.07 | 7.17 ± 0.01 | 8 |
| K+ Arrest | n/a | 0 | 0 | 7.3 ± 1.2* | 95.5 ± 3.8 | 93.0 ± 3.7 | 1.36 ± 0.04 | 7.19 ± 0.01 | 8 |
| Reperfusion | 125.4 ± 6.4 | 222.2 ± 7.4 | 28.1 ± 1.5 | 30.6 ± 3.5 | 84.9 ± 3.5* | 83.6 ± 3.1 | 1.34 ± 0.04 | 7.14 ± 0.01 | 8 |
| 40°C | |||||||||
| Control | 127.7 ± 10.9 | 294.4 ± 16.4 | 36.8 ± 5.7 | 33.5 ± 4.6 | 100 | 100 | 1.28 ± 0.07 | 7.12 ± 0.01 | 4 |
| K+ Arrest | n/a | 0 | 0 | 9.7 ± 2.4* | 103.7 ± 5.3 | 94.4 ± 0.5* | 1.40 ± 0.10 | 7.15 ± 0.01 | 4 |
| Reperfusion | 130.9 ± 12.3 | 294.2 ± 26.3 | 37.4 ± 5.1 | 34.1 ± 3.2 | 76.0 ± 2.4* | 87.2 ± 5.1* | 1.12 ± 0.06 | 7.10 ± 0.02 | 4 |
LVDP, left ventricular developed pressure; HR, heart rate; RPP, rate pressure product; PCr, phosphocreatine.
*
Indicates statistical significance.