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Reduced renal histopathology after renal I/R in the absence of cathepsin G. Kidneys from 129/SvJ wild-type and cathepsin G−/− mice were subjected to unilateral ischemia for 60 minutes. Kidneys were retrieved 24 hours after reperfusion, and formalin-fixed sections of a kidney from a normal wild-type mouse (a), contra-lateral (b) and ischemic (c) kidneys from wild-type mice, and an ischemic kidney from cathepsin G−/− mouse (d) were prepared and stained with H&E. Magnification, ×200.
