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Diagram of TcsL-82 mechanism of action on lung vascular endothelial cells. TcsL-82 after intraperitoneal injection is recognized by a still unknown receptor at the surface vascular endothelial cells. This large clostridial toxin is then endocytosed, and its enzymatic domain (N-terminal part) is translocated into the cytosol72 where it glucosylates Rac and Ras proteins (Ras, Rap, Ral) and depolymerizes the actin cytoskeleton, thereby modifying adherens junctions (AJ).
