Table 2.
TcsL-82 Modifies Hematological Parameters
| Hematological parameters | Control mice (n = 10) | TcsL-82 intoxicated mice (n = 12) | Wilcoxon signed-rank test P value (two-tailed) |
|---|---|---|---|
| Hemoglobin (g/dl) | 11.06 ± 1.72 | 15.38 ± 2.06 | 0.0002 |
| Hematocrit (%) | 36.47 ± 6.39 | 50.71 ± 4.9 | 0.0002 |
| Red blood cells (103/mm3) | 6.22 ± 1.07 | 8.51 ± 0.72 | 0.0002 |
| White cells (103/mm3) | 5.40 ± 2.5 | 8.39 ± 2.8 | 0.0017 |
| Granulocytes (×103/mm3) | 1.22 ± 0.62 | 2.37 ± 1.08 | 0.0002 |
| Platelets (×103/mm3) | 1204 ± 388 | 644 ± 397 | 0.0012 |
| Monocytes (×103/mm3) | 0.23 ± 0.1 | 0.65 ± 027 | 0.0005 |
| Lymphocytes (×103/mm3) | 4.1 ± 1.8 | 5.5 ± 1.9 | 0.076 (NS) |
Hematological parameters and differential leukocyte counts were measured in control and in mice intoxicated for 6 hours with TcsL-82 (15 ng i.p.). For that purpose, blood samples were collected on EDTA and a cell automated complete blood Vet’ABC blood counter was used. n, the number of mice analyzed in each group. Results were analyzed by the Wilcoxon signed-rank test using arbitrarily the median of controls as the hypothetical value for comparison. The P value is given and considered as significant when equal or smaller than 0.05.