Table 3.
Interaction analysis between smoking and GSTO1, GSTO2, and GSTM1: Caucasians
| Never-Regular Smoked (n=219) | Ever-Regular Smoked1 (n=236) | |||||
|---|---|---|---|---|---|---|
| Polymorphism | Cases/Ctrls | OR | 95% CI | Cases/Ctrls | OR | 95% Confidence Interval |
| GSTO1-140 (rs4925) | ||||||
| CC | 61/38 | 1 | ref | 64/58 | 0.66 | (0.38–1.14) |
| AC+AA | 67/53 | 0.77 | (0.44–1.32) | 43/71 | 0.36 | (0.21–0.63) |
| Interaction OR | 0.55 | (0.33–0.92) | ||||
| GSTO2 (rs2297235) | ||||||
| AA | 63/38 | 1 | ref | 63/56 | 0.65 | (0.37–1.12) |
| AG+GG | 65/53 | 0.72 | (0.42–1.25) | 44/73 | 0.35 | (0.20–0.61) |
| Interaction OR | 0.54 | (0.32–0.90) | ||||
| GSTM12 | ||||||
| *1 | 61/49 | 1 | ref | 60/65 | 0.72 | (0.43–1.21) |
| *0 | 67/42 | 1.28 | (0.74–2.21) | 47/64 | 0.57 | (0.33–0.97) |
| Interaction OR | 0.78 | (0.47–1.31) | ||||
OR, odds ratio adjusted for sex and age at diagnosis (continuous)
1
Ever-regular smoked is defined as smoking cigarettes for at least one year.
2
*0 signifies homozygous gene deletion