Figure 1.

(A) Chemical structure of the 10S (+)-trans-anti-[BP]-N²-dG adduct. Torsion angles α′ and β′ are defined as follows: α′, N1–C2–N²–C10(BP); β′, C2–N²–C10(BP)–C9(BP). The glycosidic torsion angle is denoted by χ, defined as O4′-C1′-N9-C4. (B) The sequences and numbering system of the 12-mer duplexes containing the 10S (+)-trans-anti-[BP]-N²-dG adduct. The lesion sites are marked G6* and G7*. The sequences are referred to as G6*G7 and G6G7*.