Table 1.

List of proteins showing significantly altered expression in Neuro-2a-Ng cells

Protein name	Accession No.	Total Ion Score C.I. %	Averaged ICAT ratio*(H/L)
Up-regulated
Gag	IPI00118848	100	1.832
Gag protein	IPI00466581	99.999	1.814
T-complex protein 1 subunit epsilon	IPI00116279	99.378	1.826
Similar to Hsp60, mitochondrial precursor	IPI00461249	56.155	1.663
Heterogeneous nuclear ribonucleoprotein U	IPI00458583	99.895	1.547
Similar to aspartate aminotransferase, mitochondrial precursor	IPI00475310	100	1.542
Aspartate aminotransferase, mitochondrial precursor	IPI00117312	100	1.512
Down-regulated
Beta-centractin	IPI00153990	73.581	0.681
Tubulin beta-3	IPI00112251	99.993	0.67
Tubulin beta-2c chain	IPI00169463	99.451	0.67
Tubulin alpha-2 chain	IPI00551116	99.740	0.517
Tubulin alpha-4 chain	IPI00117350	99.369	0.516
Elongation factor 1-alpha 1	IPI00307837	98.991	0.561
Elongation factor 2	IPI00466069	100	0.486
Microtubule-associated protein 1B	IPI00130920	92.545	0.272
Hsp105	IPI00224109	80.993	0.559
Hsp70	IPI00331556	78.526	0.559
GTP-binding nuclear protein Ran	IPI00134621	80.728	0.646
Peptidyl-prolyl cis-trans isomerase	IPI00458341	100	0.619
T-complex protein 1 subunit gamma	IPI00116283	90.604	0.591
Tyrosine 3-monooxygenase/ tryptophan 5- monooxygenase activation protein, zeta polypeptide	IPI00473203	99.88	0.562
Ubiquitin carboxyl-terminal hydrolase isozyme L1	IPI00313962	100	0.515
Isoform 1 of cellular nucleic acid binding protein	IPI00330767	96.078	0.478
Fructose-bisphosphate aldolase A	IPI00221402	88.547	0
Isoform 2 of zinc finger X-chromosomal protein	IPI00134496	31.306	0

*H/L represents the abundance ratio between heavy isotope (¹³C) labeled proteins (Neuro-2a-Ng) and light isotope (¹²C) labeled proteins (Neuro-2a control). The averaged ICAT ratios equal to or higher than 1.5 (up-regulated expression) or, alternatively, equal to or lower than 0.7 (down-regulated expression) represent a significant change in protein expression in Neuro-2a-Ng cells relative to control cells.