TABLE 3.

Changes in mRNA Expression of Angiogenic Growth Factors in Mouse Prostate at Different Times after Testosterone Replacement

	CTL*	T day 1*	T day 3*	T day 10*
VEGF-A	1.00 ± 0.16	2.79 ± 0.11	2.49 ± 0.18	3.69 ± 0.07
VEGF-B	1.00 ± 0.09	1.18 ± 0.05	1.52 ± 0.21	1.58 ± 0.11
VEGF-C	1.00 ± 0.04	1.80 ± 0.17	1.83 ± 0.08	1.93 ± 0.11
VEGF-D	1.00 ± 0.02	0.60 ± 0.01	0.95 ± 0.13	0.61 ± 0.12
PlGF	1.00 ± 0.11	4.09 ± 0.06	3.15 ± 0.22	3.33 ± 0.15
VEGFR-1	1.00 ± 0.05	1.25 ± 0.19	1.60 ± 0.13	1.46 ± 0.27
VEGFR-2	1.00 ± 0.11	1.65 ± 0.42	3.89 ± 0.22	2.35 ± 0.21
FGF-2	1.00 ± 0.04	3.56 ± 0.14	6.08 ± 0.48	2.54 ± 0.28
FGF-8	1.00 ± 0.08	6.10 ± 0.30	13.9 ± 0.27	12.0 ± 0.36
HGF	1.00 ± 0.09	1.17 ± 0.20	1.23 ± 0.50	0.97 ± 0.72
Ang-1	1.00 ± 0.15	1.23 ± 0.21	0.82 ± 0.09	0.51 ± 0.17
Ang-2	1.00 ± 0.19	0.93 ± 0.28	1.35 ± 0.04	1.21 ± 0.24
Tie-2	1.00 ± 0.22	1.71 ± 0.11	3.56 ± 0.23	2.20 ± 0.34

Mean ± SEM, n=3. The mean derived value for each gene in the CTL group was arbitrarily designated as “1”.

^*CTL, prostates from 10 day-castrated mice; T day 1, T day 3, T day 10, prostates from mice 1, 3, or 10 days after testosterone treatment.